Cosmetics Efficacy Clinical Study Team
Conduct evaluation on the functional cosmetics, quasi-drugs, antibacterial function, in addition to stability and effectiveness test on the cosmetic ingredients at once!
Cell efficacy evaluation
The Clinical Evaluation Service Center of the Korea Institute of Dermatological Sciences conducts the human studies for products and the efficacy evaluation on the ingredients from various kinds of skin cells and immune cells to examine the cell signaling and delivery process from genes and protein. We help apply the appropriate ingredients to the industry and make contributions to the advancement of basic science by submitting patents and academic theses in and outside of Korea through the newly-identified intracellular mechanism research.
Collagen expression productivity
- Collagen genes expression analysis (RT-PCR)
- MMP genes expression analysis (RT-PCR)
- Collagen and MMPs Western blot analysis
Tyrosinase
activity inhibition test
- Tyrosinase, TRP-1/2, MITF gene expression analysis(RT-PCR)
Intracellular melanogenesis inhibition test
- In-vitro antioxidation evaluation on protein analysis (Western blot) in regard to melanogenesis including tyrosinase
- Measurement of intracellular NO (Nitric Oxide) synthesis and antioxidation using DPPH
Cytotoxicity test
- Cytotoxicity and viability evaluation through WST-1 assay and FACS analysis
| Primary cellular efficacy evaluation system | |
|---|---|
| Cytotoxicity and cellular multiplication test |
Evaluation method : Cytotoxicity and viability evaluation through WST-1 assay and FACS analysis Applicable cells : Dermal fibroblast, melanoblast, macrophage, lipocyte, dermal papilla cell, corneocyte |
| Anti-wrinkle efficacy test |
Evaluation method: Intracellular collagen production test, Collagenase activity inhibition test Applicable cells: Dermal fibroblast |
| Whitening effect test |
Evaluation method : Measurement of intracellular NO (Nitric Oxide) synthesis and antioxidation using DPPH Applicable cells : Monocyte/macrophage, splenocyte, dermal fibroblast |
| Seconary cellular efficacy evaluation system | ||
|---|---|---|
| Cellular multiplication and healing test | Identify cellular multiplication and intracellular signaling & delivery process in regard to healing |
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| Anti-wrinkle efficacy and anti-aging test | Identify intracellular signaling & delivery process in regard to anti-wrinkle and anti-aging |
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| Whitening effect test | Identify intracellular signaling & delivery process in regard to whitening effect |
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| Cellular multiplication and healing test | Currently, more than 15 different test methods are under development. | |